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已知普鲁卡因酰胺胶囊的生物利用度为0.85,药物消除半衰期(t½)为3.5小时,表观分布容积为2.0L/kg。若患者每4小时口服给药1次,欲保持平均稳态血药浓度为6mg/L,则给药剂量应为()

发布日期:2020-08-20

已知普鲁卡因酰胺胶囊的生物利用度为0.85,药物消除半衰期(t½)为3.5小时,表观分布容积为2.0...
A

8.72mg/kg

B

9.53mg/kg

C

10.24mg/kg

D

11.18mg/kg

E

12.56mg/kg

试题解析

盐酸普鲁卡因酰胺

盐酸普鲁卡因酰胺Procainamide,为Ⅰa类抗心律失常药物,对心脏自律性、传导性、兴奋性及膜反应作用类似奎尼丁。

药品名称
盐酸普鲁卡因酰胺
外文名
Procainamide
别名
普鲁卡因酰胺;奴佛卡因胺;阿米山林;普鲁司太尔;普鲁卡因胺;盐酸盐酸普鲁卡因酰胺;Amidoprocaine
剂型
1.注射剂:0.1g,0.2g,0.5g,1.0g2.片剂:0.25g

生物利用度

生物利用度是指制剂中药物被吸收进入人体循环的速度与程度。生物利用度是反映所给药物进入人体循环的药量比例,它描述口服药物由胃肠道吸收,及经过肝脏而到达体循环血液中的药量占口服剂量的百分比。包括生物利用程度与生物利用速度。

中文名
生物利用度
释义
药物吸收入人体循环的速度与程度
外文名
bioavailability
包括
生物利用程度和速度

药物

药物(Medicines)是一类药水,它可以去除特定的效果,而不是应用效果。

中文名
药物
类型
药水
是否可堆叠
外文名
Medicines
是否可再生
数据值
DEC:447 HEX:1BF BIN:110111111

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此试题出现在

药学正副高

临床药学(医学高级)

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